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Hello Health Nerds,

Today we’re talking about Intermittent Fasting!

In this week’s newsletter, we discuss

 🔬 What the science says about Intermittent Fasting (IF)

 🥦 The different ways to do IF

👩🏼‍🔬 What health experts think about IF

Deep Dive on Intermittent Fasting

Intermittent fasting (IF) has surged in popularity, not just as a weight loss strategy but as a comprehensive approach to improving overall health. This method cycles between periods of eating and fasting, varying from a few hours to several days. Let’s explore how IF enhances metabolic health, its impact on longevity and cognitive function, and examine the various IF protocols along with their specific uses, benefits, and challenges.

Science Behind Intermittent Fasting

Intermittent fasting positively impacts metabolic health by modulating key hormones:

  • Insulin: Fasting periods help lower insulin levels, facilitating fat burning.

  • Growth Hormone: Increases in this hormone during fasting periods promote fat loss and muscle preservation.

  • Norepinephrine: This hormone rises during fasting, enhancing the metabolic rate which can aid in weight loss.

These hormonal adjustments contribute to not only weight reduction but also improved heart health by influencing factors such as blood pressure and cholesterol levels.

Additionally, IF supports longevity and brain health through:

  • Autophagy: This process, activated during fasting, helps cells clear out damaged parts, which can decrease the risk of several diseases including neurodegenerative and metabolic disorders.

  • Brain-Derived Neurotrophic Factor (BDNF): Fasting boosts levels of BDNF, enhancing learning, memory, and the growth of new brain cells, thereby supporting cognitive function.

1. 16/8 Method (Leangains protocol)

  • How It Works: Fast for 16 hours each day and eat during an 8-hour window.

  • When to Use: Ideal for those aiming to lose weight without drastic changes to their diet.

  • Pros: Easier to adhere to and less disruptive to social activities.

  • Cons: Skipping breakfast might be challenging; possible overeating during the eating window.

2. 5:2 Diet (Fast Diet)

  • How It Works: Eat normally for 5 days, restrict calories to about 500-600 for two days.

  • When to Use: Suitable for those who prefer minimal disruption to their weekly eating patterns.

  • Pros: Flexibility in choosing fasting days.

  • Cons: Possible extreme hunger on low-calorie days; potential binge eating on non-fasting days.

3. One Meal a Day (OMAD or 24-hour fast)

  • How It Works: Consume one meal per day within a very short eating window or fast completely for 24 hours.

  • When to Use: Fits those looking for significant calorie reduction.

  • Pros: Potentially substantial reduction in calorie intake.

  • Cons: May induce fatigue, headaches, or irritability due to prolonged fasting.

4. Alternate-Day Fasting (ADF)

  • How It Works: Alternate between no restrictions one day and reduced caloric intake the next.

  • When to Use: For quick results and those who can manage strict fasting regimes.

  • Pros: Quick weight loss, enhanced insulin sensitivity.

  • Cons: Difficult to sustain; may disrupt social and work life.

5. The Warrior Diet

  • How It Works: Fast all day and eat one large meal at night within a 4-hour window.

  • When to Use: Best for those who naturally prefer eating at night.

  • Pros: Supports natural eating rhythms; can improve dietary control.

  • Cons: Risk of overeating; not ideal for those with sensitive blood sugar levels.

6. Spontaneous Meal Skipping

  • How It Works: Skip meals when convenient, essentially following hunger cues rather than a strict schedule.

  • When to Use: Great for beginners or those seeking a highly flexible approach.

  • Pros: Adapts easily to personal schedules, intuitive.

  • Cons: May lead to inconsistent nutrient intake.

Thoughts on Intermittent Fasting from Leading Experts

Andrew Huberman, Ph.D. 
Dr. Andrew Huberman has discussed the neurobiological effects of intermittent fasting on brain function and overall health. He notes that intermittent fasting can enhance cognitive function and stress resilience by influencing neuronal circuits that manage brain health and energy metabolism. Huberman often explains how fasting can lead to increased levels of BDNF (Brain-Derived Neurotrophic Factor), which is crucial for brain plasticity.

Bryan Johnson 
Bryan Johnson has also delved into the realm of biohacking and has shown interest in practices like intermittent fasting as part of a broader pursuit of enhancing physical and mental performance. Johnson, known for his focus on extending life and improving quality of life through various health optimizations, sees intermittent fasting as a method to reduce inflammation, improve metabolic health, and optimize brain function. He often integrates fasting with other health practices to pursue an optimized lifestyle.

Peter Attia, M.D. 
Dr. Peter Attia is a strong advocate for intermittent fasting, often discussing its benefits in delaying aging and improving metabolic health. Attia talks about how fasting can enhance insulin sensitivity, reduce the risk of chronic diseases like type 2 diabetes, and potentially extend lifespan. He frequently shares insights from both personal experiences and scientific studies to back his views on fasting.

Rhonda Patrick, Ph.D. 
Rhonda Patrick has expressed both interest and caution regarding intermittent fasting. She emphasizes the importance of understanding individual nutritional needs and health conditions when considering fasting. Patrick highlights that while intermittent fasting can lead to improved health markers, such as reduced inflammation and better lipid profiles, it's not suitable for everyone, especially pregnant women or those with certain health issues.

David Sinclair, Ph.D.
David Sinclair delves deeper into the biological mechanisms behind intermittent fasting, particularly its impact on the aging process. He explains that fasting doesn’t just help in trimming down body fat but also plays a crucial role in activating sirtuins, a group of proteins linked to aging and cellular health. Sinclair emphasizes that these proteins help regulate cellular repair and gene expression in response to dietary patterns and stress. By fasting, we may enhance our body's ability to repair its DNA and clean out cellular waste, processes that are vital for reducing age-related diseases and extending lifespan. He also touches on the concept of fasting mimicking diets, which replicate the effects of fasting without needing to abstain from food completely, suggesting they offer similar benefits in terms of promoting longevity and metabolic health. This approach to intermittent fasting, Sinclair suggests, could be a feasible method for those looking to gain the benefits of fasting with less frequent dietary restriction.

For a comprehensive look at Intermittent Fasting, including extended fasts that last 3 or 5 days, check out our detailed article on Intermittent Fasting over at routines.club.

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The Routines team